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BCMA (human) :Fc (human), (recombinant)

Product Specifications

Product Name Alternative

TNFRSF 17, B cell maturation protein, CD269

Certification

RUO

UniProt

Q02223

Source

Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.

Stability

Stable for at least 6 months after receipt when stored at -20°C.

Concentration

1 mg/mL after reconstitution.

Purity

≥95% (SDS-PAGE)

Reconstitution

Reconstitute with 50μl of sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Molecular Weight

~40kDa (SDS-PAGE) .

Shipping Conditions

Blue Ice

Storage Conditions

-20°C

Notes

Historical data shows that it blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.

Specificity

Binds human and mouse BAFF and APRIL.

Formulation

Lyophilized. Contains PBS.

Applications Notes

ELISA: binds to mouse BAFF) . Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to IgG1.

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