Atpenin A5 (synthetic)
Product Specifications
CAS Number
119509-24-9
Product Name Alternative
3-[ (2S,4S,5R) -5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2 (1H) -pyridinone
Certification
RUO
Target
Mitochondrial complex
Type
Inhibitor
Source
Synthetic. Originally isolated from Penicillium sp. strain FO-125.
Stability
As indicated on product label or CoA when stored as recommended.
Purity
≥95% (HPLC)
Solubility
Soluble in acetone, acetonitrile, chloroform, ethyl acetate, DMSO, methanol or 100% ethanol; insoluble in water or hexane.
Molecular Formula
C 15 H 21 Cl 2 NO 5
Molecular Weight
366.2
Shipping Conditions
Ambient Temperature
Storage Conditions
-20°C
Notes
The IC 50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC 50 value of carboxin (1.1μM) ) . It also inhibits fumarate reductase of Ascaris suum (IC 50 = 12nM) . Inhibition of E. coli succinate dehydrogenase is less potent (IC 50 = 5μM) .By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial K ATP channels.
Appearance
White to off-white powder.
RTECS
CJ8800000
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470633-100 1x 100 µL
Von Willebrand Factor (3E2D10), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680806-100 1x 100 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470460-100 1x 100 µL
CD44 Standard (156-3C11), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880158-500 1x 500 µL
Cytokeratin 17 (E3), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940050-100 1x 100 µL
IgA Secretory Component (SC05), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details