AMPIVIEW® PD-L1 (AS) Dig RNA Probes Set

AMPIVIEW ® PD-L1 (AS) Dig RNA Probes are optimized for amplification with DIGX ® anti-digoxigenin Linker and detection with POLYVIEW ® PLUS detection reagents combined with HIGHDEF ® chromogens and counterstains (not included) . Dilutions and concentration optimization can be done with AMPIVIEW ® hybridization buffer, included in this set.

AMPIVIEW ® PD-L1 (AS) Dig RNA probes have been designed to target the nucleic acid of CD274 gene which encodes the Programmed Death-Ligand 1 (PD-L1) protein, for its detection in tissues and cells. PD-L1 binds to its receptor Programmed Cell Death 1 (PD-1) on T cells to inhibit T call activation, suppress immune responses and maintenance of immune tolerance. Many tumors overexpress PD-L1 to evade the immune detection and allow for cancer cells to grow and spread. Immunotherapy drugs block PD-L1, restoring T cell activity and enabling the iimmune system to attack tumors. AMPIVIEW ® PD-L1 (AS) Dig RNA probes are conjugated with digoxigenin and have been optimized to be amplified with DIGX ® anti-Digoxigenin linker and detected with POLYVIEW ® PLUS combined with HIGHDEF ® chromogens and counterstain to produce clear results that can be visualized with a light microscope.