EB1

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2) . EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].

Product Specifications

CAS Number

[42951-68-8]

UNSPSC

12352005

Target

Apoptosis; Eukaryotic Initiation Factor (eIF) ; MNK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eb1.html

Purity

99.91

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2

Molecular Formula

C18H14N4

Molecular Weight

286.33

References & Citations

[1]Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65 (8) :6070-6087. |[2]Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129:106126.