SC-57461A
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively[1].
Product Specifications
CAS Number
423169-68-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sc-57461a.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1.[H]Cl
Molecular Formula
C20H26ClNO3
Molecular Weight
363.88
Precautions
H302, H315, H319
References & Citations
[1]Leslie J Askonas, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4- (phenylmethyl) phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A (4) hydrolase I: in vitro studies. J Pharmacol Exp Ther. 2002 Feb;300 (2) :577-82.|[2]T D Penning. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des. 2001 Feb;7 (3) :163-79.|[3]James F Kachur, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4- (phenylmethyl) phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A (4) hydrolase II: in vivo studies. J Pharmacol Exp Ther. 2002 Feb;300 (2) :583-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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