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Citrullinated amyloid-β (1-40) peptide (human)

Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40) ) is a modified form of β-Amyloid (1-40) with a citrullination at the Arg5 site. Citrullinated amyloid-β (1-40) peptide (human) exhibits increased transient formation of soluble oligomers and insoluble aggregates composed of distorted parallel β-sheets compared with unmodified β-Amyloid (1-40).

Product Specifications

Product Name Alternative

Citrullinated Aβ (1-40) ; Citrullinated Aβ40

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/citrullinated-amyloid-β-1-40-peptide-human.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(C)C(NC(CCC(O)=O)C(NC(CC1=CC=CC=C1)C(NC(CCCNC(N)=O)C(NC(CC2=CNC=N2)C(NC(CC(O)=O)C(NC(CO)C(NCC(NC(CC3=CC=C(C=C3)O)C(NC(CCC(O)=O)C(NC(C(C)C)C(NC(CC4=CNC=N4)C(NC(CC5=CNC=N5)C(NC(CCC(N)=O)C(NC(CCCCN)C(NC(CC(C)C)C(NC(C(C)C)C(NC(CC6=CC=CC=C6)C(NC(CC7=CC=CC=C7)C(NC(C)C(NC(CCC(O)=O)C(NC(CC(O)=O)C(NC(C(C)C)C(NCC(NC(CO)C(NC(CC(N)=O)C(NC(CCCCN)C(NCC(NC(C)C(NC(C(C)CC)C(NC(C(C)CC)C(NCC(NC(CC(C)C)C(NC(CCSC)C(NC(C(C)C)C(NCC(NCC(NC(C(C)C)C(NC(C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(CC(O)=O)N

Molecular Formula

C194H294N52O59S

Molecular Weight

4330.79

References & Citations

[1]Osaki D, Hiramatsu H. Citrullination and deamidation affect aggregation properties of amyloid β-proteins. Amyloid. 2016 Dec;23 (4) :234-241.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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