Mazdutide (IBI362, LY330567)
Product Specifications
CAS Number
2259884-03-0
Synonyms
IBI-362; LY-3305677; OXM-3
SKU
C18487-5mg
Target
Glucagon Receptor
Applications
GPCR & G Protein
Molecular Formula
C210H322N46O67
Additionnal Information
Mazdutide (IBI-362; LY-3305677) is a synthetic long-acting oxyntomodulin analog that functions as a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) . The compound exhibits binding affinity for human and mouse GCGR (Ki values of 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki values of 28.6 nM and 25.1 nM, respectively) . In mouse islets, mazdutide stimulates insulin secretion with an EC50 of 5.2 nM. This agent has been investigated in research related to obesity and type 2 diabetes (T2D) .
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