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DS18561882

Product Specifications

CAS Number

2227149-22-4

SKU

C18296-1mg

Smiles

CS (=O) (NC1=CC=C (C (N2CCC (C3=CC=C (N4C[C@H] (C) N (C) CC4) C (C) =C3O5) =C (C5=O) C2) =O) C=C1OC (F) (F) F) =O

Molecular Formula

C28H31F3N4O6S

Additionnal Information

DS18561882 is a potent, isozyme-selective, and orally available inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with an IC50 value of 0.0063 μM. It exhibits complete tumor growth inhibition in a mouse xenograft model, and shows potential as an anti-cancer agent.

Available Sizes

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