Ropsacitinib (PF-06826647)
Product Specifications
CAS Number
2127109-84-4
Synonyms
Tyk2-IN-8, compound 10
SKU
C18274-10mM/1mL
Target
JAK
Applications
Angiogenesis
Smiles
CN1C=C (C=N1) C2=CN3C (=CC=N3) C (=N2) C4=CN (N=C4) C5 (CC (C5) C#N) CC#N
Molecular Formula
C20H17N9
Additionnal Information
Ropsacitinib (PF-06826647, Tyk2-IN-8, compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF-06826647 (Tyk2-IN-8, compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF-06826647 (Tyk2-IN-8, compound 10) is used in the treatment of psoriasis (PSO) .
Storage Conditions
3 years -20°C powder
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