GLPG1837
Product Specifications
CAS Number
1654725-02-6
Synonyms
ABBV-974
SKU
C18215-25mg
Target
CFTR
Applications
Transmembrane Transporters
Smiles
CC1 (CC2=C (C (O1) (C) C) SC (=C2C (=O) N) NC (=O) C3=CC=NN3) C
Molecular Formula
C16H20N4O3S
Additionnal Information
GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.
Storage Conditions
2 years -80 in solvent
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