TH588
Product Specifications
CAS Number
1609960-31-7
SKU
C18005-25mg
Target
MTH1
Applications
DNA Damage/DNA Repair
Smiles
C1CC1NC2=NC (=NC (=C2) C3=C (C (=CC=C3) Cl) Cl) N
Molecular Formula
C13H12Cl2N4
Additionnal Information
TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Storage Conditions
2 years -80 in solvent
Available Sizes
Frequently Asked Questions
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