What is the catalog number for GSK J1?

The catalog number for GSK J1 is C17988.

What sizes are available for GSK J1?

GSK J1 is available in the following size(s): 200 mg.

GSK J1 is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for GSK J1?

GSK J1 is requires dry ice shipping.

GSK J1

Product Specifications

CAS Number

1373422-53-7

SKU

C17988-200mg

Target

Histone Demethylase

Applications

Epigenetics

Smiles

C1CN (CCC2=CC=CC=C21) C3=NC (=NC (=C3) NCCC (=O) O) C4=CC=CC=N4

Molecular Formula

C22H23N5O2

Additionnal Information

GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B), respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.