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Purmorphamine

Product Specifications

CAS Number

483367-10-8

Synonyms

Shh Signaling Antagonist VI

SKU

C17179-1g

Target

Autophagy

Applications

Autophagy

Smiles

C1CCC (CC1) N2C=NC3=C (N=C (N=C32) OC4=CC=CC5=CC=CC=C54) NC6=CC=C (C=C6) N7CCOCC7

Molecular Formula

C31H32N6O2

Additionnal Information

Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.

Storage Conditions

2 years -80 in solvent

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