Laduviglusib (CHIR-99021) Hydrochloride
Product Specifications
CAS Number
1797989-42-4
Synonyms
CT99021 HCl
SKU
C17149-10mM/1mL
Target
GSK-3
Applications
PI3K/Akt/mTOR
Smiles
CC1=CN=C (N1) C2=CN=C (N=C2C3=C (C=C (C=C3) Cl) Cl) NCCNC4=NC=C (C=C4) C#N.Cl
Molecular Formula
C22H18Cl2N8.HCl
Additionnal Information
Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.
Storage Conditions
2 years -80 in solvent
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