Carfilzomib (PR-171)

Product Specifications

CAS Number

868540-17-4

SKU

C17102-100mg

Target

Proteasome

Applications

Proteases

Smiles

CC (C) CC (C (=O) C1 (CO1) C) NC (=O) C (CC2=CC=CC=C2) NC (=O) C (CC (C) C) NC (=O) C (CCC3=CC=CC=C3) NC (=O) CN4CCOCC4

Molecular Formula

C40H57N5O7

Additionnal Information

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.