BI-D1870

Product Specifications

CAS Number

501437-28-1

SKU

C17096-10mg

Target

S6 Kinase

Applications

MAPK

Smiles

CC1C (=O) N (C2=CN=C (N=C2N1CCC (C) C) NC3=CC (=C (C (=C3) F) O) F) C

Molecular Formula

C19H23F2N5O2

Additionnal Information

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.