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MK-5108

Product Specifications

CAS Number

1010085-13-8

Synonyms

VX-689

SKU

C17055-10mg

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

C1CC (CCC1OC2=C (C (=CC=C2) Cl) F) (CC3=NC (=CC=C3) NC4=NC=CS4) C (=O) O

Molecular Formula

C22H21ClFN3O3S

Additionnal Information

MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.

Storage Conditions

2 years -80 in solvent

Available Sizes

Curated Selection

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