MK-5108
Product Specifications
CAS Number
1010085-13-8
Synonyms
VX-689
SKU
C17055-10mg
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
C1CC (CCC1OC2=C (C (=CC=C2) Cl) F) (CC3=NC (=CC=C3) NC4=NC=CS4) C (=O) O
Molecular Formula
C22H21ClFN3O3S
Additionnal Information
MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.
Storage Conditions
2 years -80 in solvent
Available Sizes
Curated Selection
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