Dacomitinib

Product Specifications

CAS Number

1110813-31-4

Synonyms

PF299804, PF299

SKU

C17028-10mg

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

COC1=C (C=C2C (=C1) N=CN=C2NC3=CC (=C (C=C3) F) Cl) NC (=O) C=CCN4CCCCC4

Molecular Formula

C24H25ClFN5O2

Additionnal Information

Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.