Trametinib (GSK1120212)
Product Specifications
CAS Number
871700-17-3
Synonyms
JTP-74057
SKU
C16991-10mM/1mL
Target
MEK
Applications
Protein Tyrosine Kinase
Smiles
CC1=C2C (=C (N (C1=O) C) NC3=C (C=C (C=C3) I) F) C (=O) N (C (=O) N2C4=CC=CC (=C4) NC (=O) C) C5CC5
Molecular Formula
C26H23FIN5O4
Additionnal Information
Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.
Storage Conditions
2 years -80 in solvent
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