NU7441 (KU-57788)

Product Specifications

CAS Number

503468-95-9

SKU

C16971-10mg

Target

DNA-PK

Applications

PI3K/Akt/mTOR

Smiles

C1COCCN1C2=CC (=O) C3=C (O2) C (=CC=C3) C4=CC=CC5=C4SC6=CC=CC=C56

Molecular Formula

C25H19NO3S

Additionnal Information

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.