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Rabusertib (LY2603618)

Product Specifications

CAS Number

911222-45-2

Synonyms

IC-83

SKU

C16960-10mg

Target

Chk

Applications

Cell Cycle

Smiles

CC1=CC (=C (C=C1Br) NC (=O) NC2=NC=C (N=C2) C) OCC3CNCCO3

Molecular Formula

C18H22BrN5O3

Additionnal Information

Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.

Storage Conditions

2 years -80 in solvent

Available Sizes

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