Ixazomib (MLN2238)
Product Specifications
CAS Number
1072833-77-2
SKU
C16684-10mg
Target
Proteasome
Applications
Proteases
Smiles
B (C (CC (C) C) NC (=O) CNC (=O) C1=C (C=CC (=C1) Cl) Cl) (O) O
Molecular Formula
C14H19BCl2N2O4
Additionnal Information
Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.
Storage Conditions
2 years -80 in solvent
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