Orantinib (SU6668)

Product Specifications

CAS Number

252916-29-3

Synonyms

TSU-68

SKU

C16335-10mg

Target

PDGFR

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (NC (=C1CCC (=O) O) C) C=C2C3=CC=CC=C3NC2=O

Molecular Formula

C18H18N2O3

Additionnal Information

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.