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Danusertib (PHA-739358)

Product Specifications

CAS Number

827318-97-8

SKU

C16114-10mg

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

CN1CCN (CC1) C2=CC=C (C=C2) C (=O) NC3=NNC4=C3CN (C4) C (=O) C (C5=CC=CC=C5) OC

Molecular Formula

C26H30N6O3

Additionnal Information

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.

Storage Conditions

2 years -80 in solvent

Available Sizes

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