Adezmapimod (SB203580)
Product Specifications
CAS Number
152121-47-6
Synonyms
RWJ 64809, PB 203580
SKU
C16092-50mg
Target
P38 MAPK
Applications
MAPK
Smiles
CS (=O) C1=CC=C (C=C1) C2=NC (=C (N2) C3=CC=NC=C3) C4=CC=C (C=C4) F
Molecular Formula
C21H16FN3OS
Additionnal Information
Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3 (106T) and SAPK4 (106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.
Storage Conditions
3 years-20°C (in the dark) powder
Available Sizes
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