Pazopanib HCl

Product Specifications

CAS Number

635702-64-6

Synonyms

GW786034 HCl

SKU

C16069-25mg

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (C=C (C=C1) NC2=NC=CC (=N2) N (C) C3=CC4=NN (C (=C4C=C3) C) C) S (=O) (=O) N.Cl

Molecular Formula

C21H23N7O2S.HCl

Additionnal Information

Pazopanib HCl is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.