ABT-737

Product Specifications

CAS Number

852808-04-9

SKU

C16051-100mg

Target

Bcl-2

Applications

Apoptosis

Smiles

CN (C) CCC (CSC1=CC=CC=C1) NC2=C (C=C (C=C2) S (=O) (=O) NC (=O) C3=CC=C (C=C3) N4CCN (CC4) CC5=CC=CC=C5C6=CC=C (C=C6) Cl) [N+] (=O) [O-]

Molecular Formula

C42H45ClN6O5S2

Additionnal Information

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.