DC260126

Product Specifications

CAS Number

346692-04-4

SKU

C16004-25mg

Target

GPR

Applications

GPCR & G Protein

Smiles

CCCCC1=CC=C (C=C1) NS (=O) (=O) C2=CC=C (C=C2) F

Molecular Formula

C16H18FNO2S

Additionnal Information

DC260126, a small organic antagonist for GPR40 (FFAR1), dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50=6.28, 5.96, 7.07, 4.58 μM, respectively), reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.