BBO-8520
Product Specifications
CAS Number
2893809-51-1
SKU
C14710-1mg
Target
Ras
Applications
Apoptosis
Smiles
FC1=[C@] (C (C (F) (F) F) =CC2=C (N=C (N=C21) OC[C@@]34CCCN3C[C@@H] (C4) F) N5[C@H] (CN ([C@@H] (C5) C) C (C=C) =O) C) [C@]6=CC=C (F) C7=C6C (C#N) =C (N) S7
Molecular Formula
C35H33F6N7O2S
Additionnal Information
BBO-8520 is a covalent small molecule inhibitor that selectively targets KRAS G12C with high oral bioavailability. It functions as both a KRAS G12C (OFF) inhibitor and a blocker of KRAS G12C (ON) signaling. The compound inhibits cellular proliferation by binding to GTP-bound KRAS G12C (ON), thereby preventing RAS-RAF1 interaction and promoting the transition to the inactive (OFF) state .
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