DCPIB

Product Specifications

CAS Number

82749-70-0

SKU

C14627-25mg

Target

Potassium Channel

Applications

Transmembrane Transporters

Smiles

CCCCC1 (CC2=CC (=C (Cl) C (=C2C1=O) Cl) OCCCC (O) =O) C3CCCC3

Molecular Formula

C22H28Cl2O4

Additionnal Information

DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC) . DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker of I (Cl, swell), which blocks native I (Cl, swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC (50) of 4.1 μM.