Motixafortide (BL-8040)
Product Specifications
CAS Number
664334-36-5
Synonyms
BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140
SKU
C14397-5mg
Target
CXCR
Applications
GPCR & G Protein
Smiles
C1CC2C (=O) NC (C (=O) NC (C (=O) NC (C (=O) NC (CSSCC (C (=O) NC (C (=O) NC (C (=O) NC (C (=O) NC (C (=O) N2C1) CCCCN) CCCCN) CCCNC (=O) N) CC3=CC=C (C=C3) O) NC (=O) C (CC4=CC5=CC=CC=C5C=C4) NC (=O) C (CCCNC (=N) N) NC (=O) C (CCCNC (=N) N) NC (=O) C6=CC=C (C=C6) F) C (=O) NC (CCCNC (=N) N) C (=O) N) CCCNC (=O) N) CCCNC (=N) N) CC7=CC=C (C=C7) O
Molecular Formula
C97H144FN33O19S2
Additionnal Information
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ~1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
Storage Conditions
3 years -20°C powder
Available Sizes
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