What is the catalog number for ACBI1?

The catalog number for ACBI1 is C14362.

What sizes are available for ACBI1?

ACBI1 is available in the following size(s): 5 mg, 10 mM / 1 mL, 25 mg, 100 mg.

How many pack sizes does ACBI1 come in?

ACBI1 is available in 4 different pack sizes.

ACBI1 is currently made to order / not held in immediate stock. Contact us for lead time.

ACBI1

Product Specifications

CAS Number

2375564-55-7

SKU

C14362-5mg

Target

PROTAC

Applications

Others

Smiles

CC1=C (SC=N1) C2=CC (=C (CNC (=O) C3CC (O) CN3C (=O) C (NC (=O) C4 (F) CC4) C (C) (C) C) C=C2) OCCOC5=CC=C (CN6CCN (CC6) C7=C (N) N=NC (=C7) C8=C (O) C=CC=C8) C=C5

Molecular Formula

C49H58FN9O7S

Additionnal Information

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.