HLM006474
Product Specifications
CAS Number
353519-63-8
SKU
C13822-5mg
Target
CDK
Applications
Cell Cycle
Smiles
CCOC1=C (C=C (C=C1) C (C2=C (C3=C (C=CC (=N3) C) C=C2) O) NC4=CC=CC=N4) C
Molecular Formula
C25H25N3O2
Additionnal Information
HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 μM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.
Storage Conditions
3 years -20°C powder
Available Sizes
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