SR-4835
Product Specifications
CAS Number
2387704-62-1
SKU
C13758-5mg
Target
CDK
Applications
Cell Cycle
Smiles
CN1C=C (C=N1) N2C=NC3=C (N=C (N=C32) N4CCOCC4) NCC5=NC6=CC (=C (C=C6N5) Cl) Cl
Molecular Formula
C21H20Cl2N10O
Additionnal Information
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
Storage Conditions
3 years -20°C powder
Available Sizes
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