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SR-4835

Product Specifications

CAS Number

2387704-62-1

SKU

C13758-5mg

Target

CDK

Applications

Cell Cycle

Smiles

CN1C=C (C=N1) N2C=NC3=C (N=C (N=C32) N4CCOCC4) NCC5=NC6=CC (=C (C=C6N5) Cl) Cl

Molecular Formula

C21H20Cl2N10O

Additionnal Information

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.

Storage Conditions

3 years -20°C powder

Available Sizes

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