What is the catalog number for VU661013?

The catalog number for VU661013 is C13646.

What sizes are available for VU661013?

VU661013 is available in the following size(s): 5 mg, 10 mM / 1 mL, 25 mg, 100 mg.

How many pack sizes does VU661013 come in?

VU661013 is available in 4 different pack sizes.

Is VU661013 in stock?

VU661013 is currently made to order / not held in immediate stock. Contact us for lead time.

VU661013

Product Specifications

CAS Number

2131184-57-9

SKU

C13646-5mg

Target

Bcl-2

Applications

Apoptosis

Smiles

CC1CN (C (=O) C2=C (C3=C (N12) C (=C (C=C3) Cl) C4=C (N (N=C4C) C) C) CCCOC5=CC (=C (C (=C5) C) Cl) C) C6=CN (C7=C6C=C (C=C7) C (=O) O) C

Molecular Formula

C39H39Cl2N5O4

Additionnal Information

VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.