Avitinib (Abivertinib)

Product Specifications

CAS Number

1557267-42-1

Synonyms

AC0010

SKU

C13632-5mg

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CN1CCN (CC1) C2=C (C=C (C=C2) NC3=NC4=C (C=CN4) C (=N3) OC5=CC=CC (=C5) NC (=O) C=C) F

Molecular Formula

C26H26FN7O2

Additionnal Information

Avitinib (Abivertinib) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM) . It has comparable anti-tumor activity and tolerated toxicity.