Avitinib (Abivertinib)
Product Specifications
CAS Number
1557267-42-1
Synonyms
AC0010
SKU
C13632-5mg
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CN1CCN (CC1) C2=C (C=C (C=C2) NC3=NC4=C (C=CN4) C (=N3) OC5=CC=CC (=C5) NC (=O) C=C) F
Molecular Formula
C26H26FN7O2
Additionnal Information
Avitinib (Abivertinib) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM) . It has comparable anti-tumor activity and tolerated toxicity.
Storage Conditions
3 years -20°C powder
Available Sizes
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