Pralsetinib (BLU-667)

Product Specifications

CAS Number

2097132-94-8

Synonyms

CS 3009, Gavreto

SKU

C13611-2mg

Target

C-RET

Applications

Protein Tyrosine Kinase

Smiles

CC1=CC (=NN1) NC2=NC (=NC (=C2) C) C3CCC (CC3) (C (=O) NC (C) C4=CN=C (C=C4) N5C=C (C=N5) F) OC

Molecular Formula

C27H32FN9O2

Additionnal Information

Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T) .