RAF709
Product Specifications
CAS Number
1628838-42-5
SKU
C13593-5mg
Target
Raf
Applications
MAPK
Smiles
CC1=C (C=C (C=N1) NC (=O) C2=CC (=CC=C2) C (F) (F) F) C3=CC (=C (N=C3) OC4CCOCC4) N5CCOCC5
Molecular Formula
C28H29F3N4O4
Additionnal Information
RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.
Storage Conditions
2 years -80 in solvent
Available Sizes
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