DCA (Sodium dichloroacetate)

Product Specifications

CAS Number

2156-56-1

Synonyms

Dichloroacetic acid, bichloroacetic acid, BCA

SKU

C13540-100mg

Target

Dehydrogenase

Applications

Metabolism

Smiles

C (C (=O) [O-]) (Cl) Cl.[Na+]

Molecular Formula

C2HCl2O2.Na

Additionnal Information

DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.