AZD5153 6-hydroxy-2-naphthoic acid

Product Specifications

CAS Number

1869912-40-2

Synonyms

AZD5153 HNT salt

SKU

C13358-5mg

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

CC1C (=O) N (CCN1CCOC2=CC=C (C=C2) C3CCN (CC3) C4=NN5C (=NN=C5OC) C=C4) C.C1=CC2=C (C=CC (=C2) O) C=C1C (=O) O

Molecular Formula

C25H33N7O3.C11H8O3

Additionnal Information

AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.