Bardoxolone Methyl

Product Specifications

CAS Number

218600-53-4

Synonyms

RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me

SKU

C13177-25mg

Target

IκB/IKK

Applications

NF-κB

Smiles

CC1 (CCC2 (CCC3 (C (C2C1) C (=O) C=C4C3 (CCC5C4 (C=C (C (=O) C5 (C) C) C#N) C) C) C) C (=O) OC) C

Molecular Formula

C32H43NO4

Additionnal Information

Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.