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Nutlin-3a

Product Specifications

CAS Number

675576-98-4

Synonyms

(-) -Nutlin-3

SKU

C13164-5mg

Target

MDM2/MDMX

Applications

Apoptosis

Smiles

CC (C) OC1=C (C=CC (=C1) OC) C2=NC (C (N2C (=O) N3CCNC (=O) C3) C4=CC=C (C=C4) Cl) C5=CC=C (C=C5) Cl

Molecular Formula

C30H30Cl2N4O4

Additionnal Information

Nutlin-3a ((-) -Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.

Storage Conditions

2 years -80 in solvent

Available Sizes

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