BIX-01294 trihydrochloride

Product Specifications

CAS Number

1392399-03-9

SKU

C13117-10mg

Target

Histone Methyltransferase

Applications

Epigenetics

Smiles

CN1CCCN (CC1) C2=NC3=CC (=C (C=C3C (=N2) NC4CCN (CC4) CC5=CC=CC=C5) OC) OC.Cl.Cl.Cl

Molecular Formula

C28H38N6O2.3HCl

Additionnal Information

BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.