Picropodophyllin (PPP)

Product Specifications

CAS Number

477-47-4

Synonyms

AXL1717

SKU

C12858-5mg

Target

IGF-1R

Applications

Protein Tyrosine Kinase

Smiles

COC1=CC (=CC (=C1OC) OC) C2C3C (COC3=O) C (C4=CC5=C (C=C24) OCO5) O

Molecular Formula

C22H22O8

Additionnal Information

Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR (FGF-R, PDGF-R, OR EGF-R) . Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.