LDN-193189 2HCl
Product Specifications
CAS Number
1435934-00-1
Synonyms
DM-3189 2HCl
SKU
C12737-5mg
Target
TGF-beta/Smad
Applications
TGF-beta/Smad
Smiles
C1CN (CCN1) C2=CC=C (C=C2) C3=CN4C (=C (C=N4) C5=CC=NC6=CC=CC=C56) N=C3.Cl.Cl
Molecular Formula
C25H24Cl2N6
Additionnal Information
LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
Storage Conditions
2 years -80 in solvent
Available Sizes
Curated Selection
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