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URMC-099

Product Specifications

CAS Number

1229582-33-5

SKU

C12623-5mg

Target

LRRK2

Applications

Autophagy

Smiles

CN1CCN (CC1) CC2=CC=C (C=C2) C3=CC4=C (NC=C4C5=CC6=C (C=C5) NC=C6) N=C3

Molecular Formula

C27H27N5

Additionnal Information

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy.

Storage Conditions

2 years -80 in solvent

Available Sizes

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