Fosbretabulin (Combretastatin A4 Phosphate) Disodium

Product Specifications

CAS Number

168555-66-6

Synonyms

CA 4DP

SKU

C12519-25mg

Target

Microtubule Associated

Applications

Cytoskeletal Signaling

Smiles

COC1=C (C=C (C=C1) C=CC2=CC (=C (C (=C2) OC) OC) OC) OP (=O) ([O-]) [O-].[Na+].[Na+]

Molecular Formula

C18H19O8P.2Na

Additionnal Information

Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.